Corel Pharma Chem

Kyron

Kyron range is derived from cross linked polyacrylic polymer used in pharmaceutical industry for taste masking of bitter drugs and for drug stabilization. It is white to off white fine powder, swellable in water.

Drugs like vitamin B12 degrade during storage, stabilization of such drugs can be done by Kyron polymers.

Taste masked complex of bitter drug can be used for following formulations:

Suspension
Dry syrup
Mouth dissolving tablet / Dispersible tablet / Chewable tablet

Grade
Advantages
Others

Traditional grades

Kyron T-104 T-114 T-134 T-154 T-159 T-123
Pharmacopoeia In house In house Polacrilin potassium USP Sodium polystyrene Sulphonate USP In house In house
Type Weak acid Weak acid Weak acid Strong acid Strong acid Weak base
Functionality -COO- -COO- -COO- -SO-3 -SO-3 Secondary amine
Ionic form Hydrogen Hydrogen Potassium Sodium Hydrogen Free base
Matrix Polyacrylic
copolymer
Polyacrylic
copolymer
Polyacrylic
copolymer
Polystyrene
copolymer
Polystyrene
copolymer
Polystyrene
copolymer
Moisture content (%) <10 <5 <10 <10 <10 <10
Appearance White to off white free flowing powder White to off white free flowing powder White to off white free flowing powder off White to golden yellow free flowing powder off White to golden yellow free flowing powder White to off white free flowing powder

Ready to use grades

Kyron T-111 T-112 T-112B T-113
Pharmacopoeia In house In house In House In house
Drug to be masked Ciprofloxacin Azithromycin Azithromycin Ibuprofen
Dose 250mg / 5ml 100mg / 5ml 200mg / 5ml 100mg / 5ml

Note: Ready to use grades are drug specific grades.

Traditional grades

  • Excellent taste masking of bitter drugs.
  • Fine powder taste masking.
  • Over night soaking is not required for complexation.
  • Washing of Kyron / complex is not required.
  • Provide self disintegration property to the tablets.
  • Improve stability of liquid / solid formulations.
  • Allows high drug loading.
  • Compatible with most of the drugs.
  • Very user-friendly and cost-effective.
  • Consistent quality.
  • No adverse effect on drug bioavailability.

Ready to use grades (Over traditional grades)

  • Excellent taste masking and no bitterness.
  • It increases productivity tremendously as it is only single step process.
  • No other excipients are required and very easy to formulate.
  • Superior quality and good patient compliance.
  • Only 15-20 minutes stirring with drug is required for taste masking.
  • Drying of complex is not required to formulate dry syrup.

Toxicity

Kyron range is a very high molecular weight polymer so after decomplexation it does not absorb in body and thus it has no toxicological effect.

Storage

At low temperature not exceeding 45°C. Protect from moisture.

Self Life

Traditional grades: Five years from the date of manufacturing in intact condition.
Ready to use grades: Two years from the date of manufacturing in intact condition.

Packing

5 kg, 10 kg & 20 kg corrugated box with polyethylene liner.

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