Kyron range is derived from cross linked polyacrylic polymer used in pharmaceutical industry for taste masking of bitter drugs and for drug stabilization. It is white to off white fine powder, swellable in water.
Drugs like vitamin B12 degrade during storage, stabilization of such drugs can be done by Kyron polymers.
Taste masked complex of bitter drug can be used for following formulations:
Suspension
Dry syrup
Mouth dissolving tablet / Dispersible tablet / Chewable tablet
Traditional grades
| Kyron | T-104 | T-114 | T-134 | T-154 | T-159 | T-123 |
|---|---|---|---|---|---|---|
| Pharmacopoeia | In house | In house | Polacrilin potassium USP | Sodium polystyrene Sulphonate USP | In house | In house |
| Type | Weak acid | Weak acid | Weak acid | Strong acid | Strong acid | Weak base |
| Functionality | -COO- | -COO- | -COO- | -SO-3 | -SO-3 | Secondary amine |
| Ionic form | Hydrogen | Hydrogen | Potassium | Sodium | Hydrogen | Free base |
| Matrix | Polyacrylic copolymer |
Polyacrylic copolymer |
Polyacrylic copolymer |
Polystyrene copolymer |
Polystyrene copolymer |
Polystyrene copolymer |
| Moisture content (%) | <10 | <5 | <10 | <10 | <10 | <10 |
| Appearance | White to off white free flowing powder | White to off white free flowing powder | White to off white free flowing powder | off White to golden yellow free flowing powder | off White to golden yellow free flowing powder | White to off white free flowing powder |
Ready to use grades
| Kyron | T-111 | T-112 | T-112B | T-113 |
|---|---|---|---|---|
| Pharmacopoeia | In house | In house | In House | In house |
| Drug to be masked | Ciprofloxacin | Azithromycin | Azithromycin | Ibuprofen |
| Dose | 250mg / 5ml | 100mg / 5ml | 200mg / 5ml | 100mg / 5ml |
Note: Ready to use grades are drug specific grades.
Traditional grades
- Excellent taste masking of bitter drugs.
- Fine powder taste masking.
- Over night soaking is not required for complexation.
- Washing of Kyron / complex is not required.
- Provide self disintegration property to the tablets.
- Improve stability of liquid / solid formulations.
- Allows high drug loading.
- Compatible with most of the drugs.
- Very user-friendly and cost-effective.
- Consistent quality.
- No adverse effect on drug bioavailability.
Ready to use grades (Over traditional grades)
- Excellent taste masking and no bitterness.
- It increases productivity tremendously as it is only single step process.
- No other excipients are required and very easy to formulate.
- Superior quality and good patient compliance.
- Only 15-20 minutes stirring with drug is required for taste masking.
- Drying of complex is not required to formulate dry syrup.
Toxicity
Kyron range is a very high molecular weight polymer so after decomplexation it does not absorb in body and thus it has no toxicological effect.
Storage
At low temperature not exceeding 45°C. Protect from moisture.
Self Life
Traditional grades: Five years from the date of manufacturing in intact condition.
Ready to use grades: Two years from the date of manufacturing in intact condition.
Packing
5 kg, 10 kg & 20 kg corrugated box with polyethylene liner.
